McGill University

Graduate and Postdoctoral
Studies 2008-09

14 Chemistry

Department of Chemistry
Otto Maass Chemistry Building
801 Sherbrooke Street West
Montreal, QC  H3A 2K6
Canada

Telephone: (514) 398-6999
Fax: (514) 398-3797
E-mail: graduate.chemistry@mcgill.ca
Website: www.mcgill.ca/chemistry

Chair

R.B. Lennox

Director of Graduate Studies

M.J.Damha

14.1 Staff

Emeritus Professors

T.H. Chan; B.Sc.(Tor.), M.A., Ph.D.(Princ.), F.C.I.C., F.R.S.C.

B.C. Eu; B.Sc.(Seoul), Ph.D.(Brown)

J.F. Harrod; B.Sc., Ph.D.(Birm.), F.R.S.C.

A.S. Hay; B.Sc.(Alta.), Ph.D.(Ill.), F.R.S.

R.H. Marchessault; B.Sc.(Montr.), Ph.D.(McG.), F.C.I.C., F.R.S.C.

M. Onyszchuk; B.Sc.(McG.), M.Sc.(W. Ont.), Ph.D.(Cant.), Ph.D.(McG.), F.C.I.C.

D. Patterson; M.Sc.(McG.)

A.S. Perlin; M.Sc., Ph.D.(McG.), F.C.I.C., F.R.S.C.

W.C. Purdy; B.A.(Amh.), Ph.D.(MIT), F.C.I.C.

L.E. St. Pierre; B.Sc.(Alta.), Ph.D.(Notre Dame), F.C.I.C.

M.A. Whitehead; B.Sc., Ph.D., D.Sc.(Lond.), F.C.I.C.

Professors

D.S. Bohle; B.A.(Reed College), M.Phil., Ph.D.(Auck.)

D.H. Burns; B.Sc.(Puget Sound), Ph.D.(Wash.)

I.S. Butler; B.Sc., Ph.D.(Brist.), F.C.I.C.

M.J. Damha; B.Sc., Ph.D.(McG.), F.C.I.C.

A. Eisenberg; B.S.(Wor. Poly.), M.A., Ph.D.(Princ.), F.C.I.C.

D.G. Gray; B.Sc.(Belf.), M.Sc., Ph.D.(Man.), F.C.I.C.

D.N. Harpp; A.B.(Middlebury), M.A.(Wesleyan), Ph.D. (N. Carolina), F.C.I.C.

G.E. Just; Ing.Chem.(E.T.H. Zürich), Ph.D.(W. Ont.), F.C.I.C.

R.B. Lennox; B.Sc., M.Sc., Ph.D.(Tor.), F.C.I.C.

C.J. Li; B.Sc.(Zhengzhou), M.S.(Chinese Academy of Sciences), Ph.D.(McG.)

D.M. Ronis; B.Sc.(McG.), Ph.D.(MIT)

E.D. Salin; B.Sc.(Calif.), Ph.D.(Ore.), F.C.I.C.

B.C. Sanctuary; B.Sc., Ph.D.(Br. Col.)

T.G.M. van de Ven; Kand. Doc.(Utrecht), Ph.D.(McG.),

Associate Professors

M.P. Andrews; B.Sc., M.Sc., Ph.D.(Tor.)

P. Ariya; B.Sc., Ph.D.(York)

B.A. Arndtsen; B.A.(Carl.), Ph.D.(Stan.)

C.J. Barrett; B.Sc., M.Sc., Ph.D.(Qu.)

W.C. Galley; B.Sc.(McG.), Ph.D.(Calif.)

J.L. Gleason; B.Sc.(McG.), Ph.D.(Va.)

A. Kakkar; B.Sc., M.Sc.(Chan. U., India), Ph.D.(Wat.)

J.F. Power; B.Sc., Ph.D.(C'dia)

L. Reven; B.A.(Carl.), Ph.D.(Ill.)

H. Sleiman; B.Sc.(A.U.B.), Ph.D.(Stan.)

Assistant Professors

K. Auclair; B.Sc.(U.Q.A.C.), Ph.D.(Alta)

M. Bourqui; B.Sc.(EPF Lausanne), Ph.D.(ETH Zürich)

P. Kambhampati; B.A. (Carleton College), Ph.D.(Texas)

U.M. Lindstrom; B.Sc. ,L.Chem.Eng.(Lund), Ph.D.(Stockholm)

Anthony Mittermaier; B.Sc.(Guelph), Ph.D.(Tor.)

N. Moitessier; B.A., Ph.D.(Nancy)

A. Moores; B.Sc., Ph.D.(Ecole Polytechnique, Paris)

B. Siwick; B.A.Sc. Eng. Sci., M.Sc., Ph.D.(Tor.)

P. Wiseman; B.Sc.(St. FX), Ph.D.(W. Ont.)

Lecturers

J. Finkenbine, G. Wilczek

Associate Members

J.A. Finch (Mining, Metals and Materials Engineering), O.A. Mamer (University Clinic, RVH), P. Grütter (Physics)

Adjunct Professors

Y. Guindon, R.J. Kazlauskas, R.St. J. Manley, C. Reber, I. Wharf, C.T. Yim, R. Zamboni

14.2 Programs Offered

M.Sc., Ph.D. and the M.Sc. (Applied).

The Department offers the Chemical Biology interdisciplinary graduate option, together with the Departments of Biochemistry, and Pharmacology and Therapeutics. Students interested in training in this option must first be accepted for graduate studies by one of the participating departments. Information on this option can be found at www.mcgill.ca/biochemistry/chemicalbiology.

Research in Chemistry

Members of the Department are organized into various research themes. Some of the current research interests are listed below, and are presented in much more detail on the departmental Website at www.chemistry.mcgill.ca.

Analytical - Environmental

Analytical-Environmental research at McGill entails a wide range of exciting fundamental and applied research with focus on state-of-the-art instrumental development in spectroscopy, imaging, chemometric and analytical bio-spectroscopy, artificial intelligence, ultra trace sampling, state-of-the-art atmospheric kinetics and photochemistry, thermochemical, box and cloud modelling, as well as the development and application of state-of-the-art numerical models of the chemistry of the regional and global atmosphere. Our collective research has direct implications in fields such as materials, environmental, and biomedical chemistry.

Chemical Biology

The Chemical Biology Research Activity Group is engaged in a diverse range of research topics which range from structural biology, enzymology, nucleic acid research and signalling pathways to biophysical chemistry of living tissues. Among the themes which unite the research being performed in this group is trying to learn new chemistry and physics from biological systems.

We have projects relating to pharmaceutically relevant enzymes such as those involved in Alzheimer's and antibiotic resistance; development of therapeutic agents in the control of inflammation, cancer and viral infections; the chemical biology of NO; quantification of bioenergetic markers of metabolism; self-assembly mechanisms of the HIV-1 virion capsid; liposome microarray systems to address membrane protein dynamics and recognition; studies on reactive oxygen species translocation across the aqueous/lipid membrane interface; RNAi/antisense technologies; dynamic combinatorial chemistry; protein dynamics and function; mechanistic aspects on involved in cellular adhesion and transport in membrane and zeolite channels; and cutting-edge micorsopies used to examine transport, motility, and reactivity in cells.

Chemical Physics

The research interests of the members of the Chemical Physics Thematic group are diverse, with groups focusing on high-end laser and NMR spectroscopies, kinetics and modelling of atmospheric chemical reactions, experimental and theoretical biophysical chemistry, polymers at interfaces and statistical and quantum mechanics. In the field of biophysical chemistry, single molecule spectroscopy is being used to probe enzyme function as well as DNA recombination and repair. Our recent advances in image correlation spectroscopic techniques now allow researchers to precisely follow the macromolecular dynamics in living cells. In a similar vein, breakthrough ultra-fast electron diffraction experiments have opened the window to real time observation of the making and breaking of chemical bonds. State-of-the-art multi-pulse femtosecond spectroscopy experiments are being applied to interesting and technologically important new materials such as photonic crystals and quantum dot superlattices. A molecular level picture of polymer dynamics and structure at surfaces and interfaces is being developed through theoretical modelling, high field solids NMR spectroscopy, electron microscopy and other surface characterization methods. In the area of atmospheric chemistry, the chemical transformation of the atmosphere is being modelled both experimentally and theoretically to understand how these processes are currently affecting and driving climate change. Finally, we have basic theory projects relating to the experimental work just described, as well as in transport and structure in complex colloidal or zeolite systems, protein dynamics, and fundamental issues in quantum and statistical mechanics.

Materials Chemistry

The Chemistry of Materials is a rapidly evolving domain of research. Materials Chemistry seeks to understand how composition, reactivity, and structure are related to function from a molecular perspective. The functionality of materials is expressed in a variety of areas including photonics, micro- and nano-electronics, biosystems, nanotechnology, drug delivery, catalysis, polymer science, molecular biology, and chemical and biological sensing. Activities of the Materials Chemistry Group are often broadly interdisciplinary. University-wide synergies among members of this group have led to the creation of the McGill Institute for Advanced Materials (MIAM) and the McGill Nanotools Facility. The latter comprises state-of-the-art micro/nanofabrication, atomic manipulation and high performance computing facilities. MIAM and members of the Chemistry Department have established research that links the Centre for Self Assembled Chemical Structures, the Centre for Biosensors and Biorecognition, the Centre for the Physics of Materials, and the Centre for Bone and Periodontal Research. Synthetic approaches to new materials include research in dendrimers, polynucleic acid architectures, polymers that conduct electrons or light and biopolymers. Polymer and colloid science figure prominently as does research and applications of the chemistry and physical properties of nanostructures. There is significant activity in understanding directed molecular assembly at interfaces and in the application of sophisticated spectroscopic tools to explore them.

Synthesis - Catalysis

The Synthesis/Catalysis Research Activity Group is a collective to develop the state-of-art catalysts, synthetic methodologies, reaction mechanisms, and synthetic routes for organic chemicals, natural products and materials. The following are the major research activities at McGill (1). Development of novel catalysts and catalytic reactions for highly efficient organic synthesis; Green Chemistry. This includes the study and discovery of novel transition-metal catalysts, biological catalysts, nano- and dendrimer-based catalysts for synthetic purposes; new chemical reactivity such as C-H activation, asymmetric catalysis and theory, multi-component reactions and combinatorial chemistry; innovative chemistry in alternative solvents such as water, sub-critical water, ionic liquids, and liquid CO2; photocatalytic reactions, reaction mechanisms, and physical organic chemistry; and computational chemistry (2). Synthesis of biological compounds, organic materials and natural products: Focus areas are total synthesis of natural products, synthesis of DNA and RNA analogues; synthesis of antiviral and anticancer nucleoside analogues, synthesis of amino acid and peptides; synthesis and study of carbohydrate derivatives; design, synthesis and study of speciality organic chemical and materials and study of speciality organic chemical and materials.

14.3 Admission Requirements

The minimum academic standard for admission to research thesis M.Sc., Ph.D. and the M.Sc. (Applied) degree programs is a minimum standing equivalent to a Cumulative Grade Point Average (CGPA) of 3.0 out of a possible 4.0 or a CGPA of 3.2/4.0 for the last two full-time academic years. Applicants from other institutions should have an academic background equivalent to that of a McGill graduate in the Chemistry Honours/Major programs. If possible, candidates should specify the field of research in which they are interested.

Admissions Requirements - Chemical Biology Option

As for the regular graduate programs of the participating departments, acceptance into the Chemical Biology Option consists of two steps:

1. Preliminary approval by the Department's Graduate Committee based on the student's transcript, references and other documents submitted with the application. The criteria for assessment at this level are the same as for the regular graduate programs of the participating departments.
2. Acceptance by an individual research director. For students wishing to participate in the Chemical Biology Option, the director must propose a research project for the student that provides training in the methods and philosophy of chemical biology. Project proposals are assessed by the Chemical Biology Program Committee.

14.4 Application Procedures

[Revised, Fall 2008: section begins.]

Application for Fall (September) 2009:

Open as of September 15, 2008.

· International deadline: March 1, 2009.

· Canadian deadline: June 1, 2009.

Application for Winter (January) 2009:

Open as of March 15, 2008.

· International deadline: September 1, 2008.

· Canadian deadline: October 15, 2008.

Application for Summer:

No Summer admission.

[Revised, Fall 2008: section ends.]

All inquiries concerning graduate work in the Department should be addressed to the Director of Graduate Studies, Department of Chemistry.

FINANCIAL ASSISTANCE

M.Sc. and Ph.D. Degrees

Financial assistance for accepted graduate students who do not hold fellowships or scholarships is normally available in the form of laboratory demonstratorships/assistantships, and occasionally by payment from research funds. Graduate students devote 12 hours per week (contact hours, plus grading of reports, etc.) during the academic session to their teaching duties. Financial assistance during the remainder of the year is provided from research funds. Scholarship holders, such as NSERC or awards of similar value, receive a tuition fee waiver.

M.Sc. (Applied) Degree

Financial assistance for candidates in the M.Sc. (Applied) program is not available during the two academic sessions when courses are taken, unless candidates are recipients of scholarships. During the four month project, candidates are paid at rates established by participating companies.

14.5 Program Requirements

M.Sc.* and Ph.D. Degrees

1. Students must take such examinations as may be required in (a) assigned courses given in the Department of Chemistry, (b) assigned cognate courses given in other departments. Courses are assigned after taking into consideration the student's previous training and research interest.

2. Students must successfully complete a research project and submit an acceptable thesis.

3. Students must satisfy the examiners in an oral examination on the thesis and related subjects (required only of candidates for the Ph.D. degree).

4. All the usual requirements of the Graduate and Postdoctoral Studies Office must be satisfied.

* This program requires 45 credits.

A minimum of 6 credits of course work is required; the balance of credits will be made up from either a combination of course work and thesis credits, or from thesis research credits only. There will be a minimum of 24 credits in the thesis research component.

Examinations in Chemistry

1. Examinations in assigned courses are normally taken by the candidates in December and May. In special circumstances, and with the permission of the Department and the Graduate and Postdoctoral Studies Office, they may be taken in September.

2. A candidate for the Ph.D. degree shall pass all such examinations, other than those in certain special courses, before the final year, except in special circumstances and then only with the approval of the Department.

M.Sc. (Applied) Degree

This program requires a minimum of 45 credits, 30 credits of course work (500 level and higher) plus a 15-credit project in some aspect of chemical industry, normally completed during a four month project.

In addition, students may be required to take advanced undergraduate courses if their background is deficient.

M.Sc. (Applied) in Chemistry

(45 credits)

Complementary Courses

(30 credits)

15 credits, five 3-credit CHEM courses at the 500 or 600 level.

15 credits, five 3-credit courses (500 level and higher) selected in consultation with the advisor.

Project

(15 credits)

CHEM 699

(15)

Project

M.Sc. in Chemistry (Thesis)

(45 credits)

Required Courses

(5 credits)

CHEM 650

(1)

Seminars in Chemistry 1

CHEM 651

(1)

Seminars in Chemistry 2

CHEM 688

(3)

Assessment

Complementary Courses (40 credits)

9 - 16 credits

Students will normally take 9 - 16 credits of CHEM (or approved) courses at the 500 or 600 level.

Thesis

(24 - 31 credits)

at least 24 credits, selected from:

CHEM 691

(3)

M.Sc. Thesis Research 1

CHEM 692

(6)

M.Sc. Thesis Research 2

CHEM 693

(9)

M.Sc. Thesis Research 3

CHEM 694

(12)

M.Sc. Thesis Research 4

CHEM 695

(15)

M.Sc. Thesis Research 5

CHEM 696

(6)

M.Sc. Thesis Research 6

CHEM 697

(9)

M.Sc. Thesis Research 7

CHEM 698

(12)

M.Sc. Thesis Research 8

Program Requirements - Chemical Biology Option

The curriculum of the Chemical Biology Option is structured so that in completing the option, students also complete the course requirements for the regular graduate programs in their home departments. For this reason, program requirements are listed separately for each department, even though the 'core' content in Chemical Biology (9 lecture credits plus 2 or 4 seminar credits for each program) is the same for each.

M.Sc. in Chemistry - Chemical Biology Option/Concentration

(45 credits)

Required Courses

(5 credits)

CHEM 650

(1)

Seminars in Chemistry 1

CHEM 651

(1)

Seminars in Chemistry 2

CHEM 688

(3)

Assessment

Complementary Courses

(minimum 11 credits)

2 credits, two of the following courses:

BIOC 610

(1)

Seminars in Chemical Biology 1

BIOC 611

(1)

Seminars in Chemical Biology 3

CHEM 689

(1)

Seminars in Chemical Biology 2

CHEM 690

(1)

Seminars in Chemical Biology 4

Students will take at least 3 courses from the following list, including at least 3 credits from the first two courses listed below.

CHEM 502

(3)

Advanced Bio-Organic Chemistry

CHEM 503 or PHAR 503

(3)

Drug Design and Development 1

BIOC 603

(3)

Genomics and Gene Expression

BIOC 604

(3)

Macromolecular Structure

CHEM 504 or PHAR 504

(3)

Drug Design and Development 2

CHEM 514

(3)

Biophysical Chemistry

CHEM 522

(3)

Stereochemistry

CHEM 591

(3)

Bioinorganic Chemistry

CHEM 621

(5)

Reaction Mechanisms in Organic Chemistry

CHEM 629

(5)

Organic Synthesis

CHEM 655

(4)

Advanced NMR Spectroscopy

PHAR 562

(3)

General Pharmacology 1

PHAR 563

(3)

General Pharmacology 2

PHAR 707

(3)

Molecular Pharmacology

The remaining credits may be graduate-level courses approved by the Department.

Thesis

(minimum 24 credits)

at least 24 credits, selected from:

CHEM 691

(3)

M.Sc. Thesis Research 1

CHEM 692

(6)

M.Sc. Thesis Research 2

CHEM 693

(9)

M.Sc. Thesis Research 3

CHEM 694

(12)

M.Sc. Thesis Research 4

CHEM 695

(15)

M.Sc. Thesis Research 5

CHEM 696

(6)

M.Sc. Thesis Research 6

CHEM 697

(9)

M.Sc. Thesis Research 7

CHEM 698

(12)

M.Sc. Thesis Research 8

Ph.D. in Chemistry

Required Courses

(5 credits)

CHEM 650

(1)

Seminars in Chemistry 1

CHEM 651

(1)

Seminars in Chemistry 2

CHEM 688

(3)

Assessment

Comprehensive

CHEM 701

(0)

Comprehensive Examination 1

CHEM 702

(0)

Comprehensive Examination 2

Complementary Courses

Students entering the program with a M.Sc. degree will normally take three (3) graduate-level courses. Students entering without a M.Sc. degree will normally take five (5) graduate-level courses.

Thesis

Students may be required to take advanced undergraduate courses if background deficient.

Ph.D. in Chemistry - Chemical Biology Option/Concentration

Required Courses

(9 credits)

CHEM 650

(1)

Seminars in Chemistry 1

CHEM 651

(1)

Seminars in Chemistry 2

CHEM 688

(3)

Assessment

BIOC 610

(1)

Seminars in Chemical Biology 1

BIOC 611

(1)

Seminars in Chemical Biology 3

CHEM 689

(1)

Seminars in Chemical Biology 2

CHEM 690

(1)

Seminars in Chemical Biology 4

Comprehensive

 

CHEM 701

(0)

Comprehensive Examination 1

CHEM 702

(0)

Comprehensive Examination 2

Complementary Courses

(minimum 9 credits)

Students entering the program with a M.Sc. degree will normally take three (3) graduate-level courses. Students entering without a M.Sc. degree will normally take five (5) graduate-level courses. At least 3 courses must be from the following list, including at least 3 credits from the first two courses listed below.

CHEM 502

(3)

Advanced Bio-Organic Chemistry

CHEM 503 or PHAR 503

(3)

Drug Design and Development 1

BIOC 603

(3)

Genomics and Gene Expression

BIOC 604

(3)

Macromolecular Structure

CHEM 504 or PHAR 504

(3)

Drug Design and Development 2

CHEM 514

(3)

Biophysical Chemistry

CHEM 522

(3)

Stereochemistry

CHEM 591

(3)

Bioinorganic Chemistry

CHEM 621

(5)

Reaction Mechanisms in Organic Chemistry

CHEM 629

(5)

Organic Synthesis

CHEM 655

(4)

Advanced NMR Spectroscopy

PHAR 562

(3)

General Pharmacology 1

PHAR 563

(3)

General Pharmacology 2

PHAR 707

(3)

Molecular Pharmacology

The remaining credits may be graduate-level courses approved by the Department.

Thesis

 

Students may be required to take advanced undergraduate courses if background deficient.

14.6 Courses

Students preparing to register should consult the Web at www.mcgill.ca/minerva (click Class Schedule) for the most up-to-date list of courses available; courses may have been added, rescheduled or cancelled after this Calendar went to press. Class Schedule lists courses by term and includes days, times, locations, and names of instructors.

Term(s) offered (Fall, Winter, Summer) may appear after the credit weight to indicate when a course would normally be taught. Please check Class Schedule to confirm this information.

Note:

All undergraduate courses administered by the Faculty of Science (courses at the 100- to 500-level) have limited enrolment.

The course credit weight is given in parentheses after the title.

Advanced Undergraduate Courses

Undergraduate courses may be required of a student who is admitted to a graduate program if deficiencies are perceived in the student's previous training. Descriptions of undergraduate courses may be found in the Faculty of Science section of the Undergraduate Programs Calendar.

CHEM 502 Advanced Bio-Organic Chemistry.

(3) (Winter) (3 lectures) (Prerequisite: CHEM 302) (Restriction: Not open to students who have taken CHEM 402.) This course will cover biologically relevant molecules, particularly nucleic acids, proteins, and their building blocks. In each case, synthesis and biological functions will be discussed. The topics include synthesis of oligonucleotides and peptides; chemistry of phosphates; enzyme structure and function; coenzymes, and enzyme catalysis; polyketides; antiviral and anticancer agents.

CHEM 503 Drug Design and Development 1.

(3) (Fall) (Prerequisites: CHEM 302, BIOL 200, BIOL 201 or BIOC 212, PHAR 300 or PHAR 301 or PHAR 303 or permission of instructor) (Restriction: U3 and graduate students. Students can register only with permission of coordinators. Priority: students registered in the Minor in Pharmacology) (Restriction: Not open to students who are taking or have taken PHAR 503) Interdisciplinary course in drug design and development covering chemistry, mechanisms of action and steps in drug development, principles and problems in drug design.

CHEM 504 Drug Design and Development 2.

(3) (Winter) (Prerequisite: CHEM 503 and permission of instructor) (Restriction: U3 and graduate students. Students can register only with permission of coordinators) (Restriction: Not open to students who are taking or have taken PHAR 504) Groups of 2-4 students with different backgrounds will form a team. Each team will select a lead compound, design the analogues, propose the preclinical and clinical studies, present possible untoward effects, and reasons for drug (dis)approval.

CHEM 514 Biophysical Chemistry.

(3) (Winter) (Prerequisite: CHEM 203 or CHEM 204 or CHEM 223 and CHEM 243, or permission of instructor.) (Restriction: Not open to students who have taken CHEM 404) Physical chemistry concepts needed to understand the function of biological systems at the molecular level, including the structure, stability, transport, and interactions of biological macromolecules.

CHEM 531 Chemistry of Inorganic Materials.

(3) (Winter) (3 lectures) (Prerequisite: CHEM 381) Structure, bonding, synthesis, properties and applications of covalent, ionic, metallic crystals, and amorphous solids. Defect structures and their use in synthesis of specialty materials such as electronic conductors, semiconductors, and superconductors, and solid electrolytes. Basic principles of composite materials and applications of chemistry to materials processing.

CHEM 533 Small Molecule Crystallography.

(3) (Fall) (Prerequisite: CHEM 355 or permission of instructor) Fundamentals of x-ray diffraction related to small molecule structure resolution, space groups, diffraction theory, strategies for structure solution, and refinement will be covered.

CHEM 534 Nanoscience and Nanotechnology.

(3) (Fall) (Prerequisites: CHEM 334 or PHYS 334 or permission of instructor) (Corequisites: one of CHEM 345, PHYS 357, or PHYS 446 or permission of instructor) (Restriction: Not open to students who have taken or are taking PHYS 534) Topics discussed include scanning probe microscopy, chemical self-assembly, computer modelling, and microfabrication/micromachining.

CHEM 543 Chemistry of Pulp and Paper.

(3) (Fall) (2 lectures plus a reading/research project.) (Prerequisite: CHEM 302 or permission of instructor) The industrial processes for converting wood to paper are described with emphasis on the relevant organic, physical, surface chemistry and colloid chemistry. The structure and organization of the polymeric constituents of wood are related to the mechanical, optical and other requisite properties of paper.

CHEM 547 Laboratory Automation.

(3) (Winter) (Two 1.5 hour lectures, lab) (Prerequisite: CHEM 377, equivalent or permission of instructor) Automation and data handling with respect to modern chemical laboratory instrumentation. Basic electronics, data acquisition, evaluation of laboratory needs, data processing methodologies.

CHEM 552 Physical Organic Chemistry.

(3) (Fall) (Prerequisite: CHEM 302) The correlation of theory with physical measurements on organic systems; an introduction to photochemistry; solvent and substituent effects on organic reaction rates, etc.; reaction mechanisms.

CHEM 555 NMR Spectroscopy.

(3) (Fall) (3 lectures) (Prerequisite: CHEM 355 or equivalent) Interpretation of proton and carbon-13 nuclear magnetic resonance spectroscopy in one dimension for structural identification.

CHEM 556 Advanced Quantum Mechanics.

(3) (Fall) (3 lectures) (Prerequisites: CHEM 345 and PHYS 242) Quantum mechanical treatment of species of chemical interest. Introduction to perturbation theory, both time-dependent and time-independent. Treatment of the variational principle. Introduction to atomic spectra. Chemical bonding in terms of both the valence bond and molecular orbital theory. Elementary collision theory. Interaction of radiation with molecules.

CHEM 567 Chemometrics: Data Analysis.

(3) (Winter) (2 lectures and 3 hours of laboratory) (Prerequisite: Linear Algebra and experience in some computer programming language) Topics covered include; factorial analysis of chemical spectra, pattern recognition from multisensor data, linear and nonlinear optimization for the determination of optimal reaction conditions molecular modeling, multisensor calibration, etc.

CHEM 571 Polymer Synthesis.

(3) (Winter) (3 lectures) (Prerequisite: CHEM 302 or equivalent, or permission of instructor.) A survey of polymer preparation and characterization; mechanisms of chain growth, including free radical, cationic, anionic, condensation and transition metal-mediated polymerization, and the effects of these mechanisms on polymer architecture; preparation of alternating, block, graft and stereoblock copolymers; novel macromolecular structures including dendrimers and other nanostructures.

CHEM 572 Synthetic Organic Chemistry.

(3) (Winter) (3 lectures) (Prerequisite: CHEM 382) Synthetic methods in organic chemistry and their application to the synthesis of complex molecules.

CHEM 575 Chemical Kinetics.

(3) (Winter) (3 lectures) (Prerequisites: CHEM 273 and CHEM 223/CHEM 243 (formerly CHEM 213).) Kinetic laws, measurement of reaction rates, transition state and collision theory. Elementary reactions in gas, solution and solid phases and on surfaces. Reaction mechanisms, laser techniques, molecular beams, chemiluminescence, explosions. Extensive use of computers to simulate the kinetic behaviour of chemical systems.

CHEM 581 Inorganic Topics 1.

(3) (Winter) (Prerequisite: CHEM 381) An introduction to some areas of current interest in inorganic chemistry. Each year a selection of several particularly active areas will be chosen.

CHEM 582 Supramolecular Chemistry.

(3) (Winter) (3 lectures) (Prerequisites: CHEM 222, CHEM 381) Introduction to supramolecular organization will be followed by discussions on the nature of interactions and methodologies to create ordered aggregates of high complexity. Potential of supramolecular chemistry in fabricating smart materials will be explored using specific topics including inclusion chemistry, dendrimers, molecular self-assembly and crystal engineering.

CHEM 585 Colloid Chemistry.

(3) (Winter) (Prerequisites: CHEM 345, MATH 233 and MATH 315, PHYS 241 and PHYS 242. Students who haven't taken CHEM 223 and CHEM 243 must have taken CHEM 273 or permission of instructor.) Principles of the physical chemistry of phase boundaries. Electrical double layer theory; van der Waals forces; Brownian motion; kinetics of coagulation; electrokinetics; light scattering; solid/liquid interactions; adsorption; surfactants; hydrodynamic interactions; rheology of dispersions.

CHEM 587 Topics in Modern Analytical Chemistry.

(3) (Fall) (Prerequisites: CHEM 367 and CHEM 377) Current theories of aqueous and nonaqueous solutions, with application to analytical chemistry; recent advances in analytical techniques. Topics may include: chromatography; applications of kinetics, solvent extraction and thermal analysis, with emphasis on their theoretical basis.

CHEM 591 Bioinorganic Chemistry.

(3) (Winter) (3 hours) (Prerequisite: CHEM 381) (Restriction: For Honours and Major Chemistry students or with permission) The roles of transition and main group elements in biology and medicine will be examined with an emphasis on using tools for structure and genome searching as well as becoming acquainted with experimental spectroscopic methods useful for bioinorganic chemistry such as macromolecular X-ray diffraction, EPR and EXAFS.

CHEM 593 Statistical Mechanics.

(3) (Winter) (3 lectures) (Research project) (Prerequisite: CHEM 345. Recommended: CHEM 365) Basic hypotheses of statistical thermodynamics; ideal monatomic, diatomic and polyatomic gases; Einstein and Debye models of solids; statistical theory of black-body radiation; Debye-Hückel theory of electrolyte solutions; absolute reaction rate theory of rate processes; theories of solutions.

CHEM 597 Analytical Spectroscopy.

(3) (Fall) (2 lectures; 3 hours lab) (Prerequisites: CHEM 367 and CHEM 377) The design and analytical use of spectroscopic instrumentation with respect to fundamental and practical limitations. Classical emission, fluorescence, absorption and chemical luminescence. Topics may include photo-acoustic spectroscopy, multielement analysis, X-ray fluorescence and modern multiwavelength detector systems.

CHEM 611 Inorganic Topics 2.

(4) This advanced level course surveys recent trends in inorganic chemistry. Students select a topic from the current literature, research the topic, present periodic oral reports and a final summary paper. The instructor participates as a tutor and gives occasional oral presentations on topics of his choice.

CHEM 612 Organometallic Chemistry.

(5) A first course at the graduate level in organometallic chemistry. The theory and practice of the field is treated starting from basic principles of inorganic and organic chemistry.

CHEM 619 Advanced Atmospheric Chemistry.

(4)

CHEM 621 Reaction Mechanisms in Organic Chemistry.

(5) A systematic survey of the mechanisms of the most common organic reactions from studies of reactions in the current literature.

CHEM 522 Stereochemistry.

(3) (Prerequisite: CHEM 302) (Restriction: Not open to students who have taken CHEM 623) Stereoisomers, their nomenclature and configuration. Conformational analysis, separation of stereoisomers, and stereocontrol in organic synthesis.

CHEM 629 Organic Synthesis.

(5) An advanced course in the synthesis of organic molecules with an emphasis on stereoselective transformations. Topics will include multiple bond formation, functional group interconversions, carbon-carbon bond formation and stereoselective oxidations and reductions.

CHEM 631D1 (2), CHEM 631D2 (2) Selected Topics in Analytical Chemistry.

(Students must register for both CHEM 631D1 and CHEM 631D2) (No credit will be given for this course unless both CHEM 631D1 and CHEM 631D2 are successfully completed in consecutive terms) A directed reading course with individual student-professor conferences, and intended mainly for students specializing in analytical chemistry. Topics are chosen to meet the individual needs of each student.

CHEM 634 Seminar in Advanced Materials.

(3) A series of research-level seminars about topics of current interest in advanced materials. Topics include molecular and nanoelectronics, computational approaches to materials design and property predictions, new techniques in molecular and atomic imaging, advances in materials preparation, quantum devices and quantum computing.

CHEM 636 Laboratory Automation 2.

(5) (Prerequisite: CHEM 547) Students will undertake a chemical laboratory automation project. Design and implementation problems will be discussed by the students in seminars and advanced topics in automated chemical instrumentation will be presented. Several experiments will be required.

CHEM 646 Advanced Statistical Mechanics.

(4) Intermediate and advanced topics in statistical mechanics. Material to be covered will include: graphical methods, modern theories of dense gases and liquids, static and dynamic critical phenomena, time-correlation functions, light-scattering and nonequilibrium phenomena.

CHEM 647 Physical Chemistry: Special Topic 1.

(4)

CHEM 648 Physical Chemistry: Special Topic 2.

(4)

CHEM 650 Seminars in Chemistry 1.

(1) (1 seminar) (Required of first year graduate students in Chemistry.) A seminar course designed for graduate students in chemistry which in conjunction with McGill Chemical Society will provide exposure to a broad range of special topics within the discipline.

CHEM 651 Seminars in Chemistry 2.

(1) (1 seminar) (Required of first year graduate students in Chemistry.) A seminar course designed for graduate students in chemistry which in conjunction with McGill Chemical Society will provide exposure to a broad range of special topics within the discipline.

CHEM 655 Advanced NMR Spectroscopy.

(4) (1 lecture) (Prerequisite: CHEM 555 or equivalent.) Advanced techniques of nuclear magnetic resonance spectroscopy, Fourier transform methods, multiple pulsing, two-dimensional pulse sequencing.

CHEM 661 Literature Review and Proposal.

(3) (Restriction: graduate students in Chemistry.) Students will review the relevant literature concerning their particular area of research and describe plans for future work.

CHEM 662 Research Report 1.

(3) (Restriction: graduate students in Chemistry.) Students will prepare a research proposal, and give a seminar.

CHEM 666D1 (3), CHEM 666D2 (3) Special Topics 2.

(Students must register for both CHEM 666D1 and CHEM 666D2) (No credit will be given for this course unless both CHEM 666D1 and CHEM 666D2 are successfully completed in consecutive terms) Critical and original essays are required on various subjects of current interest in chemistry.

CHEM 667 Special Topics 3.

(4) Critical and original essays are required on various subjects of current interest in chemistry.

CHEM 673 Polymers in Solutions.

(4) Thermodynamics of regular and of polymer solutions; osmotic pressure; phase separations; polymer configurations; light scattering; ultracentrifugation; viscometry; gel permeation chromatography; polyelectrolytes.

CHEM 674 Introductory Physical Chemistry - Polymers.

(4) A survey course on the structure of polymers; kinetics and mechanisms of polymer synthesis; molecular weight distributions; polymer configurations and the thermodynamics of polymer solutions; rubber, elasticity, osmometry and viscosity.

CHEM 686 Wet-End Papermaking Chemistry.

(3) (Restriction: graduate students in Chemistry or Chemical Engineering or permission of instructor) (Prerequisites: CHEM 543 and CHEM 585) Review of the chemistry of various additives used in papermaking, such as wet and dry strength agents, sizing agents, fillers, filler retention aids, antifoam agents, biocides, dyes, dewatering agents, drainage and formation aids. The course also addresses the chemistry of deinking of waste papers and the treatment of effluents.

CHEM 688 Assessment.

(3) (Restriction: Restricted to graduate students in Chemistry.) An evaluation that is completed before the end of the second year of registration.

CHEM 689 Seminars in Chemical Biology 2.

(1) (Restrictions: Open only to students registered for the M.Sc. or Ph.D. Graduate Option in Chemical Biology.) Second multidisciplinary seminar in chemical biology.

CHEM 690 Seminars in Chemical Biology 4.

(1) (Restrictions: Open only to students registered for the M.Sc. or Ph.D. Graduate Option in Chemical Biology.) Fourth multidisciplinary seminar in chemical biology.

CHEM 691 M.Sc. Thesis Research 1.

(3) Independent research work leading to writing of M.Sc. thesis for final submission to the Graduate and Postdoctoral Studies Office.

CHEM 692 M.Sc. Thesis Research 2.

(6) Independent research work leading to writing of M.Sc. thesis for final submission to the Graduate and Postdoctoral Studies Office.

CHEM 693 M.Sc. Thesis Research 3.

(9) Independent research work leading to writing of M.Sc. thesis for final submission to the Graduate and Postdoctoral Studies Office.

CHEM 694 M.Sc. Thesis Research 4.

(12) Independent research work leading to writing of M.Sc. thesis for final submission to the Graduate and Postdoctoral Studies Office.

CHEM 695 M.Sc. Thesis Research 5.

(15) Independent research work leading to writing of M.Sc. thesis for final submission to the Graduate and Postdoctoral Studies Office.

CHEM 696 M.Sc. Thesis Research 6.

(6) Independent research work leading to writing of M.Sc. thesis for final submission to the Graduate and Postdoctoral Studies Office.

CHEM 697 M.Sc. Thesis Research 7.

(9) Independent research work leading to writing of M.Sc. thesis for final submission to the Graduate and Postdoctoral Studies Office.

CHEM 698 M.Sc. Thesis Research 8.

(12) Independent research work leading to writing of M.Sc. thesis for final submission to the Graduate and Postdoctoral Studies Office.

CHEM 701 Comprehensive Examination 1.

(0) (Restriction: Ph.D. students in Chemistry.) An evaluation that is completed before the end of the third year of registration.

CHEM 702 Comprehensive Examination 2.

(0) (Restriction: Ph.D. students in Chemistry.) An evaluation that is completed before the end of the fourth year of registration.

CHEM 721 Organic Chemistry Research Seminar.

(3) Upon completion of the organic cumulative examinations, students will present a seminar on their research work (including background and future plans).

CHEM 763 Research Report 2.

(3) (Restriction: graduate students in Chemistry.) Students will present a seminar on a complete or nearly complete research project and discuss these results.


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