49 Medicine, Experimental

Division of Experimental Medicine
Department of Medicine
Lady Meredith House, Room 101
1110 Pine Avenue West
Montreal, QC  H3A 1A3
Canada

Telephone: (514) 398-3466
Fax: (514) 398-3425
E-mail: experimental.medicine@mcgill.ca
Website: www.medicine.mcgill.ca/EXPMED/expmed1.html

Chair, Department of Medicine

D.Eidelman

Director, Division of Experimental Medicine

H. Bennett

49.1 Staff

Emeritus Professors

P.T. Macklem; B.A.(Queen's), M.D., C.M.(McG.), F.R.C.P.(C)

B.E.P. Murphy; B.A., M.D.(Tor.), M.Sc., Ph.D.(McG.), F.A.C.P.(C)

C.K. Osterland; M.D.(Man.)

Professors

G. Batist; B.Sc.(Col.), M.D., C.M.(McG.), F.R.C.P.(C)

H. Bennett; B.A.(York, U.K.), Ph.D.(Brun.)

R. Blostein; M.Sc., Ph.D.(McG.)

T.M.S. Chang; B.Sc., M.D., C.M., Ph.D.(McG.), F.R.C.P.(C)

M. Cosio; B.Sc.(Oviedo), M.D.(Madrid)

A. Cybulsky; M.D.(Tor.), F.R.C.P.(C)

D. Eidelman; M.D., C.M.(McG.), F.R.C.P.(C)

A. Fuks; B.Sc., M.D., C.M.(McG.)

J. Genest, Jr.; M.D.,C.M.(McG.), F.R.C.P.(C)

V. Giguere; B.Sc., Ph.D.(Laval)

H.L. Goldsmith; B.A., B.Sc., M.A.(Oxon), Ph.D.(McG.)

D. Goltzman; B.Sc., M.D., C.M.(McG.), F.R.C.P.(C)

S.A. Grover; B.A.(Roch.), M.D., C.M.(McG.), M.P.A.(Harv.), F.R.C.P.(C)

Q.A. Hamid; M.D.(Mosul, Iraq.), Ph.D.(Lond.)

G. Hendy; B.Sc.(Sheff.), Ph.D.(Lond.)

A. Herscovics; B.Sc., Ph.D.(McG.)

J. Hiscott; B.Sc., M.Sc.(W.Ont.), Ph.D.(N.Y.)

L.J. Hoffer; B.Sc., M.D., C.M.(McG.), Ph.D.(M.I.T.)

L. Kleiman; B.Sc.(Ill.), Ph.D.(Johns Hop.)

R. Kremer; M.D., Ph.D.(Paris)

M. Levy; B.Sc., M.D., C.M.(McG.), F.R.C.P.(C)

B. Leyland-Jones; B.Sc., M.B., B.S.(Lond.), F.R.C.P.(C), F.A.C.P.

M.S. Ludwig; M.D.(Man.), F.R.C.P.(C)

S. Magder; M.D.(Tor.), F.R.C.P.(C)

O.A. Mamer; B.Sc., Ph.D.(Windsor)

E. Marliss; M.D.(Alta.), F.R.C.P.(C)

J. Martin; B.Sc., M.B., B.Ch., M.D.(Cork), F.R.C.P.(C)

J. Milic-Emili; M.D.(Milan), F.R.S.C.

W.H. Miller; A.B.(Prin.), Ph.D.(Rock.), M.D.(C'nell)

S. Mulay; M.Sc., Ph.D.(McG.)

W.J. Muller; B.Sc., Ph.D.(McG.)

A. Nepveu; B.Sc., M.Sc.(Montr.), Ph.D.(Sher.)

L. Panasci; B.Sc., M.D.(G'town)

M. Park; B.Sc., Ph.D.(Glas.)

A.C. Peterson; B.Sc.(Vic.,B.C.), Ph.D.(Br.Col.)

M.N. Pollak; M.D.,C.M.(McG.), F.R.C.P.(C)

P. Ponka; M.D., Ph.D.(Prague)

B. Posner; M.D.(Man.), F.R.C.P.(C)

W.S. Powell; B.A.(Sask.), Ph.D.(Dal.)

S. Rabbani; M.B.B.S.(King Edward Med. Coll., Lahore)

D. Radzioch; M.Sc., Ph.D.(Jagiellonian, Cracow)

M. Rasminsky; B.A.(Tor.), M.D.(Harv.), Ph.D.(Lond.)

E. Silva; M.D.(Chile), F.A.C.P.

E. Skamene; M.D., (Charles U., Czech.), Ph.D.(Czech.
Acad. of Sci.), F.R.C.P.(C), F.A.C.P.

A.D. Sniderman; M.D.(Tor.)

C. Srikant; M.Sc., Ph.D.(Madr.)

C.P. Stanners; B.Sc.(McM.), M.A., Ph.D.(Tor.)

M.M. Stevenson; B.A.(Hood), M.Sc., Ph.D.(Catholic U. of Amer.)

D.M.P. Thomson; M.D., (W. Ont.), Ph.D.(Lond.), F.R.C.P.(C)

C. Tsoukas; B.Sc.(McG.), M.Sc.(Hawaii), M.D.(Athens), F.R.C.P.(C)

M. Wainberg; B.Sc.(McG.), Ph.D.(Col.)

M. Zannis-Hadjopoulos; B.Sc., M.Sc., Ph.D.(McG.)

H. Zingg; M.D.(Basel), Ph.D.(McG.)

Associate Professors

M. Alaoui-Jamali; D.V.M.(Rabat, Morocco),
Ph.D.(René-Descartes, Paris)

S. Ali; B.Sc.(C'dia), Ph.D.(McG.)

D. Baran; M.D.C.M.(McG.), F.R.C.P.(C)

A. Bateman; B.Sc., Ph.D.(Lond.)

N. Beauchemin; B.A., B.Sc., M.Sc., Ph.D.(Montr.)

N. Bernard; B.Sc.(McG.), Ph.D.(Duke)

A.E. Clarke; M.D.(Nfld.), M.S.(Stan.), F.R.C.P.(C)

L.F. Congote; B.Sc.(Zür.), Ph.D.(Marburg)

D. Cournoyer; M.D.(Sher.), F.R.C.P.(C)

G. Di Battista, B.Sc.(C'dia), M.Sc., Ph.D.(Montr.)

F. Doualla-Bell; B.Sc., M.S., Ph.D.(Paris XI)

M.S. Featherstone; B.Sc., M.Sc.(Ott.), Ph.D.(McG.)

R. Gagnon; B.Sc.(Montr.), M.D.(Laval), D.Phil.(Oxon)

J. Galipeau; M.D.(Montr.)

A. Gatignol; M.Sc., Ph.D. (Paul Sabatier)

R. Germinario; B.A., M.Sc.(Seton Hall U., N.J.), Ph.D.(Dakota)

S.B. Gottfried; M.D.(Penn.)

J. Henderson; B.Sc., Ph.D.(McG.)

S. Hussain; M.D.(Baghdad), Ph.D.(McG.)

A.C. Karaplis; B.Sc., M.D., Ph.D.(McG.) (William Dawson Scholar)

P. Laneuville; B.Sc.(McM.), M.D.(Ott.), F.R.C.P.(C)

L. Larose; B.Sc., Ph.D.(Montr.)

M. Laughrea; B.Sc.(Laval), M.Sc., M.Phil., Ph.D.(Yale)

M. Lipman; M.D.,C.M.(McG.), F.R.C.P.(C)

D. Malo; D.V.M., M.Sc.(Montr.), Ph.D.(McG.)

M. Newkirk; B.Sc., M.Sc.(Queen's), Ph.D.(Tor.)

R. Palfree; B.Sc., M.Sc.(Lond.), Ph.D.(McG.)

K. Pantopoulos; B.Sc., Ph.D.(Aristotelian, Greece)

B.J. Petrof; M.D.(Laval)

J. Rauch; B.Sc., Ph.D.(McG.)

S. Richard; B.Sc., Ph.D.(McG.)

C.P. Rose; B.Sc.(Queen's), M.D., C.M., Ph.D.(McG.)

E. Schurr; Diplom., Ph.D.(Al. Ludwigs U., Freiburg)

G. Spurll; B.Sc.(Med.), M.D.(Man.)

P. Tonin; B.Sc., M.Sc., Ph.D.(Tor.)

M. Trifiro; B.Sc., M.D.,C.M.(McG.)

B. Turcotte; B.Sc., Ph.D.(Laval)

B.J. Ward; M.D.,C.M.(McG.), M.Sc.(Oxon), F.R.C.P.(C)

S. Wing; B.Sc., M.Sc.(McG.)

X.-J. Yang; B.Sc.(Zhejiang), Ph.D.(Shanghai)

Assistant Professors

M. Behr; B.Sc.(Tor.), M.D.(Queen's), M.Sc.(McG.)

V. Blank; B.Sc., M.Sc.(Konstanz, Germany), Ph.D.(Inst. Pasteur)

M. Blostein; M.D., C.M.(McG.)

M. Bouchard; B.Sc., Ph.D.(Laval)

L. Chalifour; B.Sc., Ph.D.(Man.), M.A.(Harv.)

S.R. Cohen; B.Sc., M.Sc., Ph.D.(McG.)

C. Couture; B.Sc., M.Sc.(Laval), Ph.D.(McG.)

W. Cupples; B.Sc.(Vic,B.C.), M.Sc.(Calg.), Ph.D.(Tor.)

S. Daly; B.Sc.(C'dia), Ph.D.(W. Ont.)

J.C. Engert; B.A.(Colby), Ph.D.(Boston)

J. Falutz; B.Sc., M.D., C.M.(McG.), F.R.C.P.(C)

E. Fixman; B.Sc.(Col.), Ph.D.(Johns Hop.)

D. Franchimont, M.D.(Liège, Belgium)

B. Gilfix; B.Sc.(Man.), Ph.D.(W. Ont.), M.D.C.M.(McG.), F.R.C.P.(C)

M. Götte; B.Sc., Ph.D.(Max-Planck)

M. Greenwood; B.Sc., M.Sc.(C'dia), Ph.D.(McG.)

C. Haston; B.Sc.(W. Ont.), M.Sc.(Tor.), Ph.D.(Texas)

A.E. Koromilas; B.Sc., Ph.D.(Aristotelian U., Greece)

L. Koski; B.Sc.(Tor.), Ph.D.(McG.)

A. Kristof; B.Sc., M.D.C.M.(McG.), F.R.C.P.(C)

U. Kumar; B.Sc., M.Sc., B.Ed.(Meerut), Ph.D. (Jodhpur)

S. Laporte; B.Sc., M.Sc., Ph.D.(Sher.)

J.-J. Lebrun; B.Sc., M.Sc., Ph.D.(Rennes, France)

S. Lemay; M.D.(Montr.), F.R.C.P.(C)

C. Liang; B.Sc., Ph.D.(Nankai)

R. Lin; B.Sc., M.Sc.(PRC), Ph.D.(C'dia)

J.-L. Liu; B.Sc., M.Sc.(Beijing), Ph.D.(McG.)

B. Mazer; B.Sc.(Col.); M.D.,C.M.(McG.), F.R.C.P.(C)

A. Mouland; B.A., B.Sc., Ph.D.(McG.)

S. Qureshi ; B.Sc., M.D.(Alta.), F.R.C.P.(C)

P. Siegel ; B.Sc., Ph.D.(McM.)

T. Takano; M.D., Ph.D.(Tokyo)

Associate Members, McGill

C. Autexier, M. Basik, D. Boivin, J. Bourbeau, P. Brodt, K. Brown, M.N. Burnier, D.H. Burns, S. Chevalier, M. Chevrette, R.-C. Chian, T. Chow, H. Clarke, J. Desbarats, D. Dufort, R. Farookhi, M.M. Frojmovic, C. Gagnon, A. Giaid, K. Glass, C. Goodyer, P. Goodyer, I. Gupta, N. Jabado, B.J. Jean-Claude, M. Kaartinen, N. Kabani, L. Lands, W. Lapp, S. Lehnert, B. Massie, M. Nagano, J. Nalbantoglu, F. Ni, T. Owens, A. Pause, H. Perrault, C. Polychronakos, R.D. Rajan, G. Rouleau, S.-H. Shen, S.L. Tan, G. Tannenbaum, H. Tenenhouse, M. Tremblay, J. White, J. Zwaagstra

Associate Members, Université de Montréal

J. Archambault, T. Bradley, R. Butterworth, M. Cayouette, P. Chartrand, J. Davignon, V. Dave, C. Deal, A. Deng, C.F. Deschepper, C. Desrosiers, J. Drouin, J. Gutkowska, P. Hamet, Z. Hanna, T. Hoang, M. Horb, P. Jolicoeur, A. Kania, C. Lazure, S. Mader, A. Makrigiannis, M. Nemer, M. Raymond, T. Reudelhuber, M. Sairam, G. Sauvageau, E. Schiffrin, N. Seidah, R.-P. Sekaly, D. Skup, G. Thibault, M. Trudel, J. Vacher, A. Veillette

Associate Members, Institut Armand Frappier, Université du Québec

S. Lemieux, L. Zamir

Associate Members, Pharmaceutical Companies

A.-F. Aubry, B. Gibbs

49.2 Programs Offered

M.Sc. in Experimental Medicine

Ph.D. in Experimental Medicine

M.Sc. - Specialization in Bioethics

Graduate Diploma in Clinical Research

49.3 Admission Requirements

For all four programs, candidates educated outside of Canada and the United States must submit GRE (General Examination) scores.

Ph.D.

Admission to graduate studies and research in Experimental Medicine is no longer solely restricted to students who wish to register for the Ph.D. degree. Candidates who hold only a Major or Honours B.Sc. degree, or an M.D. degree must necessarily apply to the M.Sc. program. Only candidates who already hold an M.Sc. may apply directly to the Ph.D. program.

Admission is based on an evaluation by the Admissions Committee, which looks for evidence of high academic achievement, and on acceptance by a research director. It is the policy of the Division that all students must be financially supported either by their supervisor or through studentships or fellowships.

In addition to the documentation currently required by the Graduate and Postdoctoral Studies Office, a letter from the candidate's research director outlining the M.Sc. or Ph.D. project is necessary.

M.Sc. (Specialization in Bioethics)

Admission to the Master's program in Bioethics, from the base discipline Medicine, shall be limited to students having degrees in Medicine, Nursing, Physical and Occupational Therapy, as well as any other professional health training degree.

For further information regarding this program, please refer to the Bioethics entry.

Graduate Diploma in Clinical Research

The diploma program is open to health care and research professionals, medical residents, pharmacists, nurses, and those with an undergraduate degree in the medical and allied sciences.

49.4 Application Procedures

Applications will be considered upon receipt of:

1. application form

2. letter of intent

3. curriculum vitae

4. transcripts

5. letters of reference (2)

6. $60 application fee

7. test results (TOEFL and GRE).

All information is to be submitted to the Departmental Office.

McGill's on-line application form for graduate program candidates is available at www.mcgill.ca/applying/graduate.

49.5 Program Requirements

M.Sc.

All students must have an annual Thesis Committee meeting, by the end of their second term of registration, and every 12 months subsequent to this.

Course Work:

A minimum of 12 course credits is required for students entering the program with a Bachelor's or M.D. degree. M.Sc. students in Experimental Medicine will have the option to fast-track to the Ph.D. after completion of 12-18 months of the Master's, and this under the conditions set out by the Department. For further information, please contact the student affairs office.

Ph.D.

Comprehensive Examination:

All students registered as Ph.D. must take and pass the Comprehensive Oral Examination, listed as course EXMD 701 in the second year of their program (and this whether they first entered as either M.Sc. or Ph.D.). Students shall give a 30-minute presentation of their Ph.D. project and then answer questions from the Oral Committee. This examination will test: (i) If the student's work is progressing satisfactorily and is of sufficiently high calibre to warrant continuation in the program, and (ii) If the student has a broad knowledge, not only of his/her own field of research, but also of related areas in her/his discipline.

Course Work:

A minimum of 12 course credits is required for
students entering the program with a prior Master's degree. Students having been fast-tracked to the Ph.D. must complete a total of 18 credits (6 credit in addition to the 12 which were originally requested upon entry into the M.Sc. program). The following courses are highly recommended: EXMD 604D1/EXMD 604D2 Recent Advances in Cellular and Molecular Biology; EXMD 610 Biochemical Methods in Medical Research.

After consultation with their research supervisor and the Director of the Division, students may choose their courses from those offered by Experimental Medicine, Physiology, Biochemistry as well as other graduate and advanced undergraduate courses in the medical and allied sciences. Where necessary, students may enrol for credit in courses offered in the physical and mathematical sciences.

Students in the third year of the Ph.D. must give a 20-minute oral presentation of their work at a Research Seminar evening. Students may be exempted from this requirement if they provide proof of having given a talk at an international conference.

M.Sc. (Specialization in Bioethics)

The curriculum is composed of required courses (for 6 credits) offered in the Biomedical Ethics Unit, bioethics courses (3 credit minimum) offered by the base department and any graduate courses required or accepted by the base department for the granting of a Master's degree, for a total of 18 to 21 credits. A minimum of 45 credits is required including the thesis.

For further information please contact the Chair, Master's Specialization in Bioethics, Biomedical Ethics Unit, 3690 Peel Street, Montreal, QC, H3A 1W9. Telephone: (514) 398-6980. Fax: (514) 398-8349. E-mail: kathleen.glass@mcgill.ca.

Graduate Diploma in Clinical Research

The Diploma consists of 30 credits, 24 of which include specific courses. The additional supplemental 6 credits are electives and may be chosen from course work available through the Division of Experimental Medicine, Department of Pharmacology and Therapeutics and Department of Epidemiology and Biostatistics.

The core element of the diploma is the Practicum in Clinical Research (18 credits). It is a six-step program with active 'clerkship' or 'intern-resident-type' participation in each component that is essential to the successful development and evaluation of a clinical trial.

Six 1-credit workshops will be provided by experts in the academic, industrial and government sectors, and cover wide-ranging issues pertinent to the conduct of clinical research.

49.6 Courses for Higher Degrees

Students preparing to register should consult the Web at www.mcgill.ca/minerva (click Class Schedule) for the most up-to-date list of courses available; courses may have been added, rescheduled or cancelled after this Calendar went to press. Class Schedule lists courses by term and includes days, times, locations, and names of instructors.

Term(s) offered (Fall, Winter, Summer) may appear after the credit weight to indicate when a course would normally be taught. Please check Class Schedule to confirm this information.

Courses with numbers ending D1 and D2

are taught in two consecutive terms (most commonly Fall and Winter). Students must register for both the D1 and D2 components. No credit will be given unless both components (D1 and D2) are successfully completed in consecutive terms.

Note:

All undergraduate courses administered by the Faculty of Science (courses at the 100- to 500-level) have limited enrolment.

The course credit weight is given in parentheses after the title.

H Denotes courses taught only in alternate years.

EXMD 502 Advanced Endocrinology.

(3) (Fall) (Prerequisite (Undergraduate): EXMD 301 or an equivalent course) This course is designed for U3 students who are in a major or honours program in anatomy, biology, biochemistry or physiology and for graduate students. A multidisciplinary approach will be used to teach biosynthesis and processing of hormones, their regulation, function and mechanism of action. The material will cover hypothalamic, pituitary, thyroid, atrial and adrenal hormones as well as prostaglandins and related substances.

EXMD 503 Advanced Endocrinology.

(3) (Winter) Study of the parathyroids, gut and pancreatic hormones and growth factors. In addition, the role of hormones and growth factors in reproduction and fetal maturation will be discussed.

EXMD 504 Biology of Cancer.

(3) (Fall) (Prerequisite (Undergraduate): A good knowledge of biology at the cellular and molecular level. Open to U3 and graduate students only) An introduction to the biology of malignancy. A multidisciplinary approach dealing with the etiology of cancer, the biological properties of malignant cells, the host response to tumour cell growth and the principles of cancer therapy.

EXMD 506 Advanced Applied Cardiovascular Physiology.

(3) (Winter) (Prerequisite (Undergraduate): PHGY 313 or by permission of Instructors) Offered in conjunction with the Department of Physiology. Current topics, methods and techniques for studying the cardiovascular system. Basic and applied cardiac electrophysiology, mechanisms of pacemaker activity, arrhythmias, the effects of drugs on cardiac functions, fetal circulation, coronary circulation, mechanics of blood flow, cardiovascular diseases, renal and neural control of the circulation, and cardiac assist devices.

EXMD 507 Advanced Applied Respiratory Physiology.

(3) (Fall) (Prerequisite: PHGY 313) Offered in conjunction with the Department of Physiology. In depth coverage of respiratory biology including: functional anatomy of the respiratory system, pulmonary statics and dynamics, chest wall and respiratory muscles, ventilation and perfusion, control of breathing, and defense mechanisms. This course is aimed at providing a solid grounding in pulmonary biology and its research applications.

EXMD 508 Advanced Topics in Respiration.

(3) (Winter) (Prerequisite: EXMD 507) Offered in conjunction with the Department of Physiology. In depth coverage of developmental physiology, pulmonary vascular physiology, biology of airway smooth muscle, respiratory epithelium and molecular biology of respiratory muscles. Dyspnea, mechanical ventilation and respiratory failure will also be covered. This course emphasizes application of respiratory biology to basic and applied research and touches on pulmonary pathophysiology.

EXMD 509 Gastrointestinal Physiology and Pathology.

(3) (Fall and Winter) (Prerequisite: Graduate students, U3 undergraduates) Course deals with various aspects of gastrointestinal and hepatic function in health and altered physiological states. The principal focus is on the recent literature pertaining to cell and molecular mechanisms underlying the motility secretory process, absorption and secretion. The molecular biology of the hepatic viruses and various aspects of colonic neoplasia will also be considered.

EXMD 510 Bioanalytical Separation Methods.

(3) (Fall) The student will be taught the capabilities and limitations of modern separation methods (gas and high-performance liquid chromatography, capillary electrophoresis, hyphenated techniques). Application of these techniques to solve analytical problems relevant to biomedical research will be emphasized, with special attention being paid to the processing of biological samples.

EXMD 511 Joint Venturing with Industry.

(3) (Winter) (Offered in conjunction with the Centre for Continuing Education) Using problem-based learning, the course examines the various business interactions between researchers and their business partners in support and development of research into commercial endeavours using models such as venture capital, business partnerships, or grants-in-aid.

EXMD 602 Techniques in Molecular Genetics.

(3) (Offered in conjunction with the Department of Experimental Medicine.) (Prerequisite (Graduate): Admission by permission of instructor.) Precise description of available methods in molecular genetics, and rationales for choosing particular techniques to answer questions posed in research proposals for targeting genes in the mammalian genome. Emphasis placed on analysis of regulation of gene expression and mapping, strategies for gene cloning. Course divided between lectures and student seminars.

EXMD 603 Seminars in Endocrinology.

(3) For graduate students to develop skills in critical reading of current literature, interpretation of research date, and seminar oganization and presentation. Staff suggest topics. Each student presents two seminars on topics of their choice, supervised by professors responsible for those topics, and one mini-symposium style presentation on any topic.

EXMD 604D1 (3), EXMD 604D2 (3) Recent Advances in Cellular and Molecular Biology.

(Students must register for both EXMD 604D1 and EXMD 604D2) (No credit will be given for this course unless both EXMD 604D1 and EXMD 604D2 are successfully completed in consecutive terms) Offered in conjunction with the Universitè de Montrèal: given Thursdays 16:00-18:00 at Institut de Recherches Cliniques de Montréal, 110 Pine West. The course is bilingual with abstracts in the other language supplied; more than half the lectures are in French. Aimed at bringing students up to date on recent aspects of cell and molecular biology including cellular organelle structure and function, molecular genetics, signal transduction, cell growth and development, and immunology.

EXMD 607 Molecular Control of Cell Growth.

(3) A course for graduate students in Experimental Medicine, Biology, Biochemistry, Microbiology and Physiology, dealing with molecular control in normal and malignant cell growth, including cell cycle and physiologcal controls (nutritional and hormonal), mammalian DNA replication, viral effects on host cell growth for DNA and RNA-tumor viruses and oncogenes, and tissue and organ growth-renewal mechanisms.

H

EXMD 608 Molecular Embryology.

(3) (Offered in conjunction with the Department of Oncology) The course will deal with the structure and function of genes whose products play key roles in the development of vertebrates and invertebrates. Particular emphasis will be paid to the embryonic axes, the action of cell surface molecules in the embryo, and the urogenital system.

EXMD 610 Biomedical Methods in Medical Research.

(3) A course intended to introduce students to a variety of basic techniques used in medical research. Lectures and demonstrations given on the purification of biologically active substances by chromatography, analysis of compounds by spectrophotometry and mass spectrometry, immunological techniques, centrifugation, cell culture, binding of hormones to receptors, molecular biology, tumor biology and electron microscopy.

H

EXMD 611D1 (3), EXMD 611D2 (3) Seminars in Oncology.

(Students must register for both EXMD 611D1 and EXMD 611D2) (No credit will be given for this course unless both EXMD 611D1 and EXMD 611D2 are successfully completed in consecutive terms) A course in cancer and allied fields aimed at familiarizing students with the current literature relevant to the biology of cancer, developing their critical abilities and providing an opportunity for presenting seminars to their peers.

EXMD 614 Environmental Carcinogenesis.

(3) Methods for identification of carcinogens, including epidemiological studies, animal modelling and molecular biomarkers, and characteristics of known environmental carcinogens (viruses, chemical and physical agents and diet). Environmental factors will be placed in the context of overall cancer risk, which involves interaction of genetics, host and environment.

EXMD 615 Membrane Carbohydrates.

(3) The structure, function and biosynthesis of glycoproteins, glycolipids and glycoaminoglycans, and the biological role of complex carbohydrates at the cell surface.

EXMD 616 Molecular and Cell Biology Topics.

(3) Structured and instructor-directed student presentations and discussions of recent advances in molecular and cellular biology. The course will reinforce the students' knowledge of currently major areas of investigation, with a focus on human disease and medical applications. Important recent publications will extend material from textbook and review articles.

EXMD 617 Workshop in Clinical Trials 1.

(1) Intensive day-long workshop discussing Industrial/Academic/Governmental interactions in the design, testing and approval of drugs.

EXMD 618 Workshop in Clinical Trials 2.

(1) Intensive day-long workshop discussing the role of the physician in drug testing.

EXMD 619 Workshop: Clinical Trials 3.

(1) Intensive day-long workshop discussing the pharmacoeconomics of drug design and testing.

EXMD 620 Clinical Trials and Research 1.

(1) Intensive day-long workshop discussing a topical subject or recent advance relevant to clinical research and the conduct of clinical trials.

EXMD 621 Seminars in Biomedical Research 1.

(3)

EXMD 622 Seminars in Biomedical Research 2.

(3)

EXMD 623 Seminars: Biomedical Research 3.

(3)

EXMD 624 Seminars in Biomedical Research 4.

(3)

EXMD 625 Clinical Trials and Research 2.

(1) Intensive day-long workshop discussing a topical subject or recent advance relevant to clinical research and the conduct of clinical trials.

EXMD 626 Clinical Trials and Research 3.

(1) Intensive day-long workshop discussing a topical subject or recent advance relevant to clinical research and the conduct of clinical trials.

EXMD 627 Practicum in Clinical Research.

(18) Six-step program: 1. Identification of the problem; 2. Experimental design; 3. Protocol development; 4. Execution of the protocol; 5. Data analysis; 6. Generation of final report with active "clerkship" participation in each component with team leaders and experts designated for each stage.

EXMD 627D1 (9), EXMD 627D2 (9) Practicum in Clinical Research.

(Students must register for both EXMD 627D1 and EXMD 627D2) (No credit will be given for this course unless both EXMD 627D1 and EXMD 627D2 are successfully completed in consecutive terms) (EXMD 627D1 and EXMD 627D2 together are equivalent to EXMD 627) Six-step program: 1. Identification of the problem; 2. Experimental design; 3. Protocol development; 4. Execution of the protocol; 5. Data analysis; 6. Generation of final report with active "clerkship" participation in each component with team leaders and experts designated for each stage.

EXMD 628 Qualitative Research Methodology.

(3) (Restriction: permission of instructor) This course explores both broad and specific theoretical and methodological issues in qualitative research inquiry. It will discuss both traditional and contemporary paradigmatic thought underlying the qualitative enterprise and it will introduce the student to some qualitative techniques and strategies for collecting, analyzing and reporting data.

EXMD 630 Economic Evaluation of Medical Technologies.

(3) (Offered in conjunction with the Department of Epidemiology and Biostatistics.) This course will cover basic costing principles including: discounting, overhead costs, downcosting, increment analysis, data sources, will teach students to critically evaluate the economic evaluation literature, and provide practical experience through case studies.

EXMD 635D1 (3), EXMD 635D2 (3) Experimental/Clinical Oncology.

(Students must register for both EXMD 635D1 and EXMD 635D2) (No credit will be given for this course unless both EXMD 635D1 and EXMD 635D2 are successfully completed in consecutive terms) The course will deal, on a site by site basis, with the incidence of cancer, present treatment, treatment outcome, underlying causes, current research and directions for development of new treatments. Chemotherapy, surgery, radiation therapy and nutrition as therapy and treatment of cancer will be included.

EXMD 640 Experimental Medicine Topic 1.

(3) Study, through guided reading, visits, practicals, assignements, of an elected and approved topic of importance in medical science.

EXMD 690 Master's Thesis Research 1.

(3)

EXMD 691 Master's Thesis Research 2.

(6)

EXMD 692 Master's Thesis Research 3.

(9)

EXMD 693 Master's Thesis Research 4.

(12)

EXMD 694 Master's Thesis Research 5.

(12)

EXMD 701 Comprehensive Oral Examination.

(0)

EXMD 701D1 (0), EXMD 701D2 (0) Comprehensive Oral Examination.

(Students must register for both EXMD 701D1 and EXMD 701D2) (No credit will be given for this course unless both EXMD 701D1 and EXMD 701D2 are successfully completed in consecutive terms) (EXMD 701D1 and EXMD 701D2 together are equivalent to EXMD 701)

Department of Physiology

PHGY 513 Cellular Immunology.

(3) (Winter) (3 hours lectures plus term paper) (Prerequisite: MIMM 314, or permission of the instructor) This course deals with cellular interactions, regulation and effector mechanisms of the normal immune response in relation to diseases and pathogenic processes. It is taught at an advanced level.

PHGY 515 Physiology of Blood 1.

(3) (Fall) (2 hours lecture plus 1 hour seminar weekly) (Prerequisite: PHGY 313 or PHGY 312 or permission of the instructor) Study of the cell and molecular physiology of hemostasis and its pathophysiology (bleeding and thrombosis). Emphases on molecular mechanisms regulating clot formation, fibrinolysis, and cell adhesion/aggregation. Experimental approaches and specific clinical disorders will be analyzed. Weekly discussions, and a major term paper.

PHGY 516 Physiology of Blood 2.

(3) (Winter) (2 hours lecture plus 1 hour seminar weekly) Bone marrow hematopoiesis, with emphasis on regulation of stem cell proliferation and differentiation along hematopoietic pathways. Formation and differentiation of red and white blood cells and some of the diseases associated with hemotopoiesis will be covered. Emphasis will be given to the molecular mechanisms involved in the normal and pathological conditions.

PHGY 517 Artificial Internal Organs.

(3) (Winter) (Prerequisite (Undergraduate): permission of instructors.) Physiological, bioengineering, chemical and clinical aspects of artificial organs including basic principles and physiopathology of organ failure. Examples: oxygenator, cardiac support, vascular substitutes, cardiac pacemaker, biomaterials and tissue engineering, biocompatibility.

PHGY 518 Artificial Cells.

(3) (Fall) (Prerequisite (Undergraduate): permission of instructors.) Physiology, biotechnology, chemistry and biomedical application of artificial cells, blood substitutes, immobilized enzymes, microorganisms and cells, hemoperfusion, artificial kidneys, and drug delivery systems. PHGY 517 and PHGY 518 when taken together, will give a complete picture of this field. However, the student can select one of these.

Department of Microbiology and Immunology

MIMM 509 Inflammatory Processes.

(3) (Winter) (3 hours of seminar) (Prerequisite: MIMM 314.) (Corequisite: PHGY 513 or MIMM 414) (This course will be given in conjunction with the Division of Experimental Medicine) This course concentrates on the non-specific aspects of the immune response, an area which is not adequately covered by the other immunology courses presented at the university. Interactions between guest researchers (from McGill and other universities) and students will be furthered.

Scheduled Graduate Seminars

Royal Victoria Hospital (1 hour per week):

Respiratory Research
Immunopathology
Endocrinology and Metabolism
Haematology Research
Renal and Electrolyte Seminar
Transplantation Conference
Gastroenterology Conference
Diabetes Conference
Chest-Cardiac Disease Conference
Clinical Endocrinology Conference
Steroid Biochemistry Research
Haematology Clinical Conference
Endocrinology and Metabolism Research Conference
Clinical Immunology Conference
Arthritis Conference
Internal Medicine
Dermatology Research
University Clinic Seminar
Cardiology Research

Montreal General Hospital (1 hour per week, or in some cases alternate week):

Gastroenterology Conference
Respiratory Diseases
Dermatology
Internal Medicine
Allergy and Immunology
Infectious Diseases
Combined Staff Conference
Haematology
Arthritis
Metabolic Diseases
Cardiac Disease
Neurology - Neurosurgery
University Medical Clinic Seminar